Imagine Imaging Toxin-Mediated Alpha-Synuclein in the Eye

Keeping an eye on Parkinson’s disease: color vision and outer retinal thickness as simple and non-invasive biomarkers

J Lin, DI Finkelstein, AJ Anderson, PY Lee, BV Bui, T Wijeratne, JE Alty, CTO Nguyen

2025-01-01

Over the last two decades, visual symptoms and retinal changes in Parkinson’s disease (PD) have emerged as important biomarkers. C..

Retinal hyperspectral imaging in mouse models of Parkinson’s disease and healthy aging

P Trlin, J Gong, KKN Tran, VHY Wong, PY Lee, A Hoang, D Zhao, LC Beauchamp, JKH Lim, A Metha, KJ Barnham, DI Finkelstein, BV Bui, P Bedggood, CTO Nguyen

2024-12-01

Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s ..

Altered Outer Retinal Structure, Electrophysiology and Visual Perception in Parkinson's Disease

KKN Tran, PY Lee, DI Finkelstein, AM McKendrick, BN Nguyen, BV Bui, CTO Nguyen

2024-01-23

Background: Visual biomarkers of Parkinson's disease (PD) are attractive as the retina is an outpouching of the brain. Although in..

Levodopa Rescues Retinal Function in the Transgenic A53T Alpha-Synuclein Model of Parkinson’s Disease

KKN Tran, VHY Wong, KA Vessey, DI Finkelstein, BV Bui, CTO Nguyen

2024-01-01

Background: Loss of substantia nigra dopaminergic cells and alpha-synuclein (α-syn)-rich intraneuronal deposits within the central..

Handling of missing data with multiple imputation in observational studies that address causal questions: Protocol for a scoping review

R Mainzer, M Moreno-Betancur, C Nguyen, J Simpson, J Carlin, K Lee

2023-02-01

Introduction Observational studies in health-related research often aim to answer causal questions. Missing data are common in the..

Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson’s disease

KKN Tran, VHY Wong, A Hoang, DI Finkelstein, BV Bui, CTO Nguyen

2023-01-01

Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of the pathological hallmarks of Parkinson’s d..

How Well Do Rodent Models of Parkinson’s Disease Recapitulate Early Non-Motor Phenotypes? A Systematic Review

TD Zhang, SC Kolbe, LC Beauchamp, EK Woodbridge, DI Finkelstein, EL Burrows

2022-12-01

The prodromal phase of Parkinson’s disease (PD) is characterised by many non-motor symptoms, and these have recently been posited ..